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KMID : 0370220090530030130
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Yakhak Hoeji
2009 Volume.53 No. 3 p.130 ~ p.137
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Biolosical Activities of Isolated Compounds from Peucedani Radix
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Kim Do-Hoon
Kim Gi-Eun
Kim Jin-Hyo
Kim Sung-Gun
Kim Ho-kyoung
Whang Wan-Kyunn
Oh O-Jin
Han Chi-Su
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Abstract
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In this study, isolation of antioxidative compounds was performed for development of anti-oxidizing agent. , , 30%, 60% MeOH, MeOH fractions were examined antioxidative activity by DPPH, test of inhibition on NO production. It was revealed that 30%, 60% MeOH and fractions had significant antioxidative activity. In 30% MeOH and 60% MeOH, fraction, six compounds were isolated and elucidated as adenosine(I), guanosine(II), peucedanol 7-O--D-apiofuranosyl(16)--glucopyranoside(III), peucedanol 7-O--D-glucopyranoside(IV), peucedanol(V) and scopoletin(VI) by physicochemical data and spectroscopic methods. (Negative FAB-MS, , ). The results from antioxidative activity screening for the each compound showed that compound IV was relatively superior antioxidant ability. In anti-inflammatory activation assay, compound III, IV, VI had concentration-dependent-activity and compound IV had superior anti-inflammatory ability. These results suggest that Peucedani Radix might be developed as a potent anti-oxidative, anti-inflammatory agents and ingredients for related functional foods.
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KEYWORD
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Peucedani Radix, antioxidative effect, Peucedanum japonicum
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